I have had Ankylosing Spondylitis for about 30 years and only several water on the knee episodes. The last time the swelling was very severe, and when it "stopped," the fluid leaked through my leg and pooled in my ankle. Now, I am suffering with no especially large knee swelling, but my leg and ankle are full of fluid and the pain is much worse than ever. It is almost as if whatever was swelling before had "popped," and the fluid now does not store in the knee for easy aspiration, but wreaks havoc with entire leg to the point that I cannot walk. Btw--I am certain that this was brought upon by trying a course of CMO supplement...it is the only thing that I have changed recently. Best Regards, John