cortizone injections

I had knee surgery 2 years ago. I have osteoarthritis in this particular knee. Since the surgery - since there is still a great deal of pain due to the arthritis I have been having cortizone injections every 3 months. Each time, I experience a "reaction" of some sort in that my entire body begins to hurt - it begins about 4 hours after the injection and lasts for 36 - 48 hours. I'm wondering if anyone else has experienced anything like this.