Overview
Aspirin, ibuprofen, naproxen, and naproxen sodium are examples of NSAIDs.
All NSAIDs work similarly: by blocking substances called prostaglandins that contribute to inflammation and pain.
Each NSAID is a different chemical, however, and each has a slightly different effect on the body.
Some NSAIDs are available over the counter, while more than a dozen others, including a subclass called COX-2 inhibitors, are available only with a prescription.
All NSAIDs can have significant side effects, so consult a doctor before taking any of these medications. For unknown reasons, some children seem to respond better to one NSAID than another. A doctor should monitor any child taking NSAIDS regularly to control JA symptoms as effectively as possible, at the optimal dose.
Detailed Description
Asprin
Also known as acetylsalicylic acid, aspirin is often used to relieve minor aches and pains, to reduce fever, and relieve imflammation. It is also used in long term, low doses as a way to prevent heart attacks, strokes and blood clot formation in patients with high risk for these conditions.
The main side effects of this drug are gastrointestinal ulcers, stomach bleeding, and tinnitus (the perception of sound within the human ear in the absence of corresponding external sound).
Ibuprofen
Most commonly sold under the trademarks Nurofen, Advil, and Motrin, ibuprofen is used for relief of symptoms of arthritis, primary dysmenorrhea, fever, and as an analgesic, especially where there is an inflammatory component.
Ibuprofen appears to have the lowest incidence of adverse reactions. Common side effects include nausea, dyspepsia, gastrointestinal ulcers, diarrhea, rash, and hypertension.
Naproxen and Naproxen Sodium
These drugs are used for the reduction of moderate to severe pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, tendinitis, and bursitis.
It works by inhibiting both the COX-1 and COX-2 enzymes.
Naproxen and naproxen sodium are marketed under various trade names such as Anaprox, Antalgin, Flanax, Miranax, Naprelan, Naprogesic, Naprosyn, Proxen, Synflex, and Xenobid.
COX-1 and COX-2 selective inhibitors
These are forms of NSAIDs that directly target the COX-1 or COX-2, enzymes responsible for inflammation and pain.
Last updated: 01-Jan-00
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